The introduction of standards in research and development leading to new products or innovative processes can be thought of as a particularly technical approach to framing scientific enterprises. At the other end of the spectrum, open science or responsible research and innovation may be initially thought of as concepts with no underlying technical approaches to support them. In reality as currently practiced, the development and use of standards engages significant non-technical aspects, needing to take into account research cultures or desired societal outcomes. Similarly, open science, and responsible research and innovation can operate using very practical and technical approaches. This essay focuses at the intersections of these concepts to try to contribute to larger discussions in both the research and governance communities as to how researchers should conduct their research, and what respective responsibilities of researchers, their institutes, and their supporters are.