The long and winding road: accidents and tinkering in software standardization

Software is based on universal principles but not its development. Relating software to hardware is never automatic or easy. Attempts to optimize software production and drastically reduce their costs (like in hardware) have been very restricted. Instead, highly-skilled and experienced individuals are ultimately responsible for project success. The long and convoluted path towards useful and … Leer más

Towards the right standards: the intersection of open science, responsible research and innovation, and standards

The introduction of standards in research and development leading to new products or innovative processes can be thought of as a particularly technical approach to framing scientific enterprises. At the other end of the spectrum, open science or responsible research and innovation may be initially thought of as concepts with no underlying technical approaches to … Leer más

When biology became engineering: adopting standards for living systems

Synthetic Biology, born in the early 2000s, aims to take biotechnology one step further by introducing, into the biological realm, conceptual frameworks from a range of engineering disciplines, including electrical, computer and industrial engineering. The goal is to be able to create complex biological objects and, for this, it is necessary to design and construct … Leer más

How to quantify a genetic firewall? A polarity‐based metric for genetic code engineering

Genetic code engineering aims to produce organisms that translate genetic information in a different way from that prescribed by the standard genetic code, which can eventually lead to organisms that operate under different genetic codes. And, if two organisms operate under different genetic codes, how likely is it that they can still correctly interpret each … Leer más

The faulty SOS response of Pseudomonas putida KT2440 stems from an inefficient RecA‐LexA interplay

Pseudomonas putida strain KT2440 is very sensitive to DNA damage and displays poor homologous recombination efficiencies. Why? This work aimed to gain insight into this deficiency, and based on the results obtained, it seems that P. putida fails to mount a strong SOS response due to the inefficacy of the crucial RecA‐LexA interplay largely tractable to the weakness … Leer más

Reconfiguration of metabolic fluxes in Pseudomonas putida as a response to sub-lethal oxidative stress

Pseudomonas putida is a soil bacterium that is frequently found in sites polluted with toxic chemicals. It is able to survive in these sites because of its ability to tolerate high levels of endogenous and exogenous oxidative stress. But, how? The answer to this question remains largely unknown. A study, recently published in The ISME Journal, … Leer más

Modelling co-translational dimerization for programmable nonlinearity in synthetic biology

Nonlinearity is fundamental in the performance of natural and synthetic biological networks, as many key functional motifs in microbial systems rely on nonlinear molecular dynamics. Nevertheless, the rational design of nonlinearity is an unmet challenge due to the lack of mathematical modelling that accounts for the mechanistic basis of nonlinearity. In this study, a model … Leer más