A model for the spatiotemporal design of gene regulatory circuits

Mathematical modeling assists the design of synthetic regulatory networks, and models that can predict the performance of a design are fundamental for synthetic biology. The predictability depends crucially on what assumptions the model considers. For example, a common assumption is to consider negligible the effects of intracellular physical space. The mathematical model described in this … Leer más

Task switching in engineered bacteria

The engineering of bio-computations in cells usually follow a one-device-one-function strategy. That is, an engineered system will only perform one pre-defined function – no matter how complex this is. In this paper, we present a design for engineering systems capable of task switching, thus moving between a number of pre-programmed functions (or “tasks”). Within our … Leer más

Synthetic Biology and evolution: friends or foes?

Synthetic biology (SB) is an engineering view on biotechnology. Although there is a lack of consensus on the definition of this emerging discipline, the most accepted one is that SB consists of designing, redesigning and constructing biological modules, systems, and machines in a predictive way, converting them into à la carte sources of products and … Leer más